テガフール・ウラシル






UFT


テガフール・ウラシル（Tegafur/Uracil）とは、テガフールとウラシルの合剤であり、多くの癌の治療に用いられる抗悪性腫瘍剤の一種である。商品名ユーエフティー(UFT)。




目次






  • 1 効能・効果


  • 2 副作用


  • 3 作用機序


  • 4 参考文献





効能・効果


頭頚部癌、胃癌、結腸・直腸癌、肝臓癌、胆嚢・胆管癌、膵臓癌、肺癌、乳癌、膀胱癌、前立腺癌、子宮頚癌



副作用


骨髄抑制、溶血制貧血等の血液障害、肝障害、脱水症状、腸炎、白質脳症等の精神神経障害、狭心症、心筋梗塞等の心障害、急性腎不全、ネフローゼ症候群、嗅覚脱失、間質性肺炎、急性膵炎、口内炎、消化管潰瘍・出血、スティーブンス・ジョンソン症候群、ライエル症候群など。



作用機序




  • テガフール
    • 体内で代謝され、5-FUになる。これがDNAの合成阻害、RNAの機能障害を引き起こす。



  • ウラシル
    • 体内での5-FUの分解を妨げ、5-FUの濃度を高く維持する。




参考文献


  • 「ユーエフティTM」添付文書・第11版（大鵬薬品）













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